The **WHO Global Influenza Surveillance & Response System (GISRS)** consists of **151 national influenza centers** across **129 countries** worldwide.
These centers share **surveillance findings, risk assessment, and corrective measures**, including **updates on seasonal flu vaccines**.
Unlike many other vaccines, **influenza vaccines must be evaluated regularly** because **influenza viruses evolve continuously**.
**WHO updates vaccine recommendations annually** to ensure **timely availability before the flu season**.
Since **it takes 6-8 months** for production, approval, and distribution, WHO issues recommendations:
For our region, the **trivalent flu vaccine** is recommended for the **2024 flu season** (monsoon/winter, starting from July).
**Targeted Influenza Subtypes:**
**Quadrivalent flu vaccines** are no longer necessary as **Influenza B (Yamagata lineage) is unlikely to be circulating** in the population.
**Flu vaccines are not 100% effective, but they significantly reduce disease severity**, especially in:
**Effectiveness varies between 50-70%** due to regular **antigenic drift** (gradual genetic changes in the virus).
In rare cases, **antigenic shift** (sudden, major genetic change) can result in a **pandemic**, like the **2009 H1N1 pandemic**.
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